Vetsulin® (porcine insulin zinc suspension)

Vetsulin® Directions

It is important that you follow the directions on the label or as provided by your veterinarian. Your veterinarian will determine your pet’s initial dose and dosing schedule based on their body weight. In dogs, the initial dose should be given once daily with, or right after, a meal. Twice daily therapy may be needed if the duration of insulin action is determined to be inadequate. In cats, the recommended starting dose is 1 to 2 IU per injection, twice daily at 12-hour intervals. For cats fed twice daily, the injections should be given concurrently with, or right after, each meal. For cats fed ad libitum, no change in feeding schedule is needed. Consistent timing of medications and feeding are key to control your pet’s blood glucose. Your veterinarian should reevaluate your pet at appropriate intervals and adjust the dose as needed.

It is very important that your insulin syringes match the concentration of the insulin that you have for your pet. Insulin comes in two concentrations: U-40 (40 units of insulin per mL) or U-100 (100 units of insulin per mL). Vetsulin® only comes as U-40, so it is imperative that the syringes match and are labeled as U-40. Using the incorrect syringe type will cause your pet to receive an incorrect dose of insulin. Unlike other types of insulin, when you remove Vetsulin® from the refrigerator you must shake (not roll) the vial thoroughly until it becomes an even milky color before drawing up the proper dose for administration. Foam on the surface of the suspension formed during shaking should be allowed to disperse before the product is used. Clumps or white particles can form in insulin suspensions: do not use the product if visible clumps or white particles persist after shaking thoroughly. General directions for insulin administration can be found here.

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Vetsulin® is also available in a pen form called VetPen®. The VetPen® is an insulin pen which allows for exact insulin dosing with each injection without needing to draw out insulin from a vial with a syringe. VetPen utilizes insulin cartridges, which are smaller than an insulin vial and help to prevent waste. According to the manufacturer, Vetsulin® cartridges should be used exclusively with VetPen® and 29G/12 MM pen needles.

Missed a Dose?

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A missed (or inadequate) dose may cause temporary recurrence of signs (such as excess thirst and urination) but is not life-threatening. Contact your veterinarian as soon as possible for advice on your pet’s next dose. If you cannot reach your veterinarian and your pet is eating and acting normal, give your pet the usual dose at the next regularly scheduled injection time.

Do not give extra or double doses, as this can cause life-threatening side effects. If you have questions about missed doses, please contact your prescribing veterinarian.

If you think you did not inject all the insulin dose into the subcutaneous space under the skin or it seems that some of the insulin came back out, the safest option is to contact your veterinarian to have them advise you on next steps.

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