How Long Does Zofran Last?

The effects of ondansetron (Zofran) may last about 8 to 12 hours. However, this can vary per person. Your doctor may recommend taking another dose after this first 8- to 12-hour period to prevent nausea for up to 1 to 2 days. Ondansetron (Zofran) is a medication that helps prevent nausea and vomiting after receiving treatments such as:

• chemotherapy
• radiation therapy
• surgery

It’s available in oral pills or tablets, drinkable liquids, and infusions given through a vein.

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Read on to learn more about how long the effects of Zofran last, how long it takes to start working, and what else to know about the medication.

Generally, Zofran lasts for up to 8 to 12 hours.

Your gastrointestinal system quickly absorbs Zofran. Your blood levels of the medication tend to be highest around 1.5 hours Trusted Source PubMed Central Highly respected database from the National Institutes of Health Go to source after taking an 8 milligram (mg) oral dose. However, Zofran can still be effective for hours after this time.

Still, exactly how long the effects of Zofran last can depend on many factors, such as:

• your body’s unique reaction
• your dosage
• the Zofran formulation you use, such as tablets or drinkable liquids (although Zofran given as a pill or infusion may be similarly effective)

Depending on your reason for taking Zofran, you may need to take one or more extra doses at certain intervals after your first dose.

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For example, if you’re undergoing chemotherapy, your doctor may recommend a repeat dose of Zofran 8 hours after your first dose. They may also then prescribe 8 mg of Zofran every 12 hours for 1 to 2 days after finishing chemotherapy.

Learn more about Zofran, including its dosage, safety, and possible side effects.

How long Zofran takes to start working can also vary per person.

Zofran can start working in as quickly as 30 minutes. However, in some cases, it can take up to 2 hours to effectively prevent nausea and vomiting.

To make sure that Zofran is effective by the time your treatment begins, experts recommend taking the medication at the following times:

Talk with a doctor if you have any questions about Zofran or experience any new symptoms after taking it.

Talk with your medical team if you feel like the medication isn’t helping or if you still experience vomiting even after taking two doses.

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If you miss a dose, take it as soon as you remember.

Never take more Zofran than your doctor has prescribed, even if you still feel nauseous. This includes not doubling your dose and not taking more frequent doses.

If you vomit within 30 minutes of taking a Zofran pill, talk with a doctor for advice. In some cases, you may be able to take another dose.

However, never take another dose if you use Zofran oral disintegrating tablets (ODT), even if you have vomited soon after taking a tablet.

Read more about effective remedies for nausea and vomiting.

Generally, the effects of ondansetron (Zofran) last around 8 to 12 hours. Depending on your reason for taking Zofran, doctors may recommend taking further doses at regular intervals for a short time period.

However, never take Zofran more often or in higher doses than your doctor has prescribed. Talk with a doctor if you vomit after taking Zofran, and do not repeat your dose unless they advise you to.

Zofran may take around 30 minutes to 2 hours to start reducing nausea.

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