Eliquis (apixaban)

Eliquis can cause mild or serious side effects. The following lists contain some of the key side effects that may occur while taking Eliquis. These lists don’t include all possible side effects.

For more information on the possible side effects of Eliquis, talk with your doctor or pharmacist. They can give you tips on how to manage any side effects that may be bothersome.

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Note: The Food and Drug Administration (FDA) tracks side effects of drugs it has approved. If you would like to notify the FDA about a side effect you’ve had with Eliquis, you can do so through MedWatch.

Mild side effects

Below is a partial list of mild side effects of Eliquis. To learn about other mild side effects, talk with your doctor or pharmacist, or view the drug’s prescribing information.

Mild side effects of Eliquis can include:

• bruising more easily than usual
• mild bleeding
• nausea
• anemia (low level of red blood cells)

Most of these side effects may go away within a few days or a couple of weeks. But if they become more severe or don’t go away, talk with your doctor or pharmacist.

Serious side effects

Serious side effects from Eliquis can occur. Call your doctor right away if you have serious side effects. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Serious side effects, which are explained below in “Side effect details,” include:

• allergic reaction
• serious bleeding
• increased risk of blood clots if you stop Eliquis treatment early*
• blood clots in your spine with spinal procedures*

* Eliquis has boxed warnings for these side effects. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous. To learn more, see the “FDA Warnings” section at the beginning of this article.

Side effects in older adults

In clinical studies of Eliquis, there were no major differences in side effects between older and younger adults.

Side effect details

You may wonder how often certain side effects occur with this drug. Here’s some detail on certain side effects this drug may cause.

For more information, refer to this article.

Allergic reaction

As with most drugs, some people can have an allergic reaction after taking Eliquis. In clinical studies, allergic reactions were rare in people taking Eliquis to prevent blood clots. It’s not known how often allergic reactions occurred in people who took a placebo (a treatment with no active drug) in clinical studies.

Symptoms of a mild allergic reaction can include:

• skin rash
• itching
• flushing

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A more severe allergic reaction is rare but possible. Symptoms of a severe allergic reaction can include:

• swelling under your skin, typically in your eyelids, lips, hands, or feet
• swelling of your tongue, mouth, or throat
• difficulty breathing

Call your doctor right away if you have a severe allergic reaction to Eliquis. Call 911 or your local emergency number if your symptoms feel life threatening or if you think you’re having a medical emergency.

Bleeding

Eliquis makes it harder for your blood to form clots, which raises your risk of bleeding. While taking Eliquis, you may notice that you bruise or bleed more easily than usual. Also, it might take longer than usual for you to stop bleeding.

Minor bleeding that can occur with Eliquis includes bleeding gums, nosebleeds, rectal bleeding, and periods that are heavier than usual.

However, bleeding can sometimes be more serious. It may even be life threatening in some cases. Keep in mind that bleeding can occur anywhere in your body.

For example, internal bleeding can happen in your stomach, intestines, abdomen, lungs, kidneys, liver, brain, joints, or eyes. And bleeding from a damaged blood vessel can build up and clot in the surrounding tissues, causing a swelling called a hematoma.

How common is bleeding with Eliquis?

Bleeding is the most common side effect of Eliquis. In clinical studies, the rates and severity of bleeding varied depending on the dosage and the condition being treated.

For more information about bleeding and other side effects of Eliquis, see the drug’s prescribing information or talk with your doctor.

When to see your doctor about bleeding

While taking Eliquis, you should contact your doctor if you have symptoms of potentially serious bleeding. These can include:

• any bleeding that’s severe, lasts a long time, or won’t stop
• frequent nosebleeds
• unexpected vaginal bleeding
• blood in your urine, which may be red, pink, or brown in color
• blood in your stool, which may be red or black, or look like tar
• vomiting blood or what looks like coffee grounds
• coughing up blood
• severe headache
• dizziness, which could be a sign of low blood pressure caused by internal bleeding

If you have any symptoms of serious bleeding, call your doctor right away. If your symptoms feel life threatening, call 911 or your local emergency number.

You should also contact your doctor if you fall and hit your head while taking Eliquis. A head injury could cause bleeding inside your skull.

Serious bleeding may sometimes need treatment with a blood transfusion. And if bleeding can’t be controlled or is life threatening, you may be given a drug to reverse the effect of Eliquis. To learn more, see the “Reversing Eliquis bleeds” section below.

Tiredness

Tiredness wasn’t reported in clinical studies of Eliquis. However, tiredness can be a symptom of blood loss or anemia, which are possible side effects of Eliquis.

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If you have tiredness while taking Eliquis, talk with your doctor. They may check you for any symptoms of internal bleeding. (See the “Bleeding” section above to learn more.) Your doctor may also test your blood to check whether you have anemia.

Water retention

Water retention wasn’t reported in clinical studies of Eliquis. However, water retention typically causes swelling that’s known as edema.

Edema can sometimes be a symptom of a blood clot, such as a deep vein thrombosis (DVT). Taking Eliquis reduces your risk of blood clots, but it’s still possible for them to form while you’re taking the drug.

A hematoma could also be mistaken for edema. Eliquis can sometimes cause a hematoma, which occurs when bleeding from a damaged blood vessel builds up and clots in the surrounding tissue. If this happens under the skin or in a muscle, it can cause a painful lump or swelling.

If you think you have water retention or edema while taking Eliquis, you should contact your doctor. If the edema is caused by a blood clot or hematoma, it may need to be treated.

Increased risk of blood clots if you stop Eliquis treatment early

Eliquis helps prevent blood from clotting. Stopping Eliquis before you’re supposed to can increase your risk of developing a blood clot. And if you have a type of irregular heartbeat called atrial fibrillation (AFib), stopping Eliquis can increase your risk of having a stroke.

Eliquis has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). A boxed warning alerts doctors and patients about drug effects that may be dangerous.

Do not stop taking Eliquis unless your doctor tells you to. If you need to stop taking Eliquis, your doctor may have you take a different drug to prevent blood clots.

For more details about this risk, see the “Eliquis precautions” section below.

Blood clots in your spine with spinal procedures

If you have a spinal procedure while taking Eliquis, you may develop a blood clot in your spine. This type of blood clot is called a spinal or epidural hematoma. It can press on your spinal cord and cause paralysis that’s long lasting or even permanent.

Eliquis has a boxed warning for this side effect. This is the most serious warning from the FDA. A boxed warning alerts doctors and patients about drug effects that may be dangerous.

Spinal procedures that can cause spinal or epidural hematoma include lumbar puncture (spinal tap) and spinal or epidural injections. A spinal tap is a procedure to test fluid from around your spinal cord. Spinal or epidural injections are used to give certain medications, such as anesthetics or pain relievers.

If you need a spinal procedure while you’re taking Eliquis, your doctor will monitor you for symptoms of blood clots. These include back pain, tingling, numbness, muscle weakness, and incontinence (loss of bladder or bowel control). Blood clots should be treated as soon as possible, so talk with your doctor right away if you experience these symptoms.

Your risk of blood clots is higher if you’ve had spinal surgery, problems with your spine, or difficult or repeated spinal procedures in the past. Other factors can also increase this risk.

For more details, see the “Eliquis precautions” section below.

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