Benadryl (diphenhydramine)

Your Benadryl dosage will depend on several factors. These include:

• the type of condition you’re using Benadryl to treat
• your age
• the form of Benadryl (see the “Benadryl Forms” section below for details)

Typically, you should use the smallest dosage that provides the desired effect.

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The following information describes the most commonly used or recommended dosages. If you’re unsure what dosage to take, ask your doctor or pharmacist.

Dosage for hay fever or allergies

• Typical dosage for adults: 25 to 50 milligrams (mg), every 4 to 6 hours.

Dosage for symptoms of the common cold (such as a runny nose or sneezing)

• Typical dosage for adults: 25 to 50 mg, every 4 to 6 hours.

Dosage for pain and itchy skin from hives, insect bites, and other causes

• Typical dosage for adults: An application of Benadryl cream, gel, or spray to the affected area up to three to four times daily.

Children’s dosage

• For hay fever or allergies:
  • Children ages 12 years and older: 25 to 50 mg, every 4 to 6 hours.
  • Children 6 to 11 years: 12.5 to 25 mg, every 4 to 6 hours.
  • Children under 6 years: Use only under the direction of a doctor.
• For symptoms of the common cold (such as a runny nose or sneezing):
  • Children ages 12 years and older: 25 to 50 mg, every 4 to 6 hours.
  • Children 6 to 11 years: 12.5 to 25 mg, every 4 to 6 hours.
  • Children under 6 years: Use only under the direction of a doctor.
• For pain and itchy skin from hives, insect bites, and other causes:
  • Children ages 2 years and older: Apply Benadryl cream, gel, or spray to the affected area up to three to four times daily.
  • Children under 2 years: Use only under the direction of a doctor.

Dosage for babies

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Over-the-counter oral Benadryl products are not approved for use in children under 6 years. Topical Benadryl products are not approved for use in children under 2 years.

Before giving Benadryl to a baby, talk with your doctor. They may want to evaluate the baby’s symptoms. Your doctor can also recommend the most appropriate dosage of Benadryl to treat a baby if necessary. (See warning below in the “Benadryl side effects” section.)

Maximum dosage

Oral Benadryl products should not be taken more than six times each day. For adults and children over 12 years of age, the maximum dosage is 300 mg each day. For children ages 6 to 12 years, the maximum is 150 mg each day.

Adults or children should not apply Benadryl products, such as the cream, gel, and spray, to their skin more than four times per day.

Tolerance

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Your body can develop a tolerance to some of the effects of Benadryl. This means your body’s response to the drug may decrease over time.

For instance, one study found that Benadryl caused sleepiness on the first day people took it. However, after they took Benadryl for 4 days, this side effect no longer occurred. This was due to tolerance.

Although tolerance to sleepiness caused by Benadryl can happen, tolerance doesn’t seem to develop for other effects of Benadryl. When used over time, Benadryl continues to work to relieve symptoms of hay fever or allergies, a runny nose, hives, and other conditions.

However, if you’re taking Benadryl frequently (on more than about 4 days per week), talk with your doctor. They may suggest other treatment options that may be more effective for you.

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