In 2018, a 33-year-old woman in the second trimester of pregnancy (18 weeks’ gestation) was referred to the Gynecology Department of the Policlinic for Students’ Healthcare, University of Pristina, for a painless lymphadenopathy on the left side of her neck. The woman denied having a fever or other signs/symptoms of infection. She lived in the urban area of Kosovska Mitrovica and reported no contact with known reservoirs of F. tularensis, although she did mention having gone for a walk and spending some time in natural areas, but not swimming, a few days before symptom onset. She denied drinking nonpotable water (e.g., spring water) and confirmed that she drank only bottled water.
Three months before pregnancy, cervical screening (including smear test and microbiology) detected no abnormalities. She had no previous pregnancies or remarkable medical or surgical history. During week 7 of gestation, a viable, eutopic, singleton pregnancy was confirmed, and at week 12, gynecologic and ultrasonography examinations and double marker, blood, urine, and biochemical testing were performed. Fetal growth corresponded with the length of the amenorrhea, and all results were within the normal range for pregnancy. Double marker testing indicated low risk for trisomies. The patient was asymptomatic. The next appointment was at week 16 of gestation, when uneventful pregnancy with constant growth velocity was confirmed.
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The painless lymphadenopathy was detected at week 18. The lymph node was mobile, ≈2 cm in diameter, and painless. Blood analysis results, including leukocytes, were within reference limits and showed no evidence of bacteremia. Nose and throat swab sample cultures showed no microbial growth.
For biopsy of the swollen lymph node, we referred the patient to the Clinic for Otorhinolaryngology and Maxillofacial Surgery at the Clinical Centre of Serbia, University of Belgrade. At the time of the transfer, she was 19 weeks pregnant, febrile, but clinically stable. Fetal growth corresponded to gestational age. Immunologic analyses, blood count, and peripheral blood smear performed by the hematologist ruled out blood disorders and systemic diseases (antinuclear antibodies were negative). Serologic analyses excluded infection caused by Epstein-Barr virus, cytomegalovirus, HIV, herpes simplex virus, and hepatitis B and C viruses. Toxoplasmosis and brucellosis were excluded by relevant testing.
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The enlarged neck node was excised with local anesthesia at week 19 of gestation. Histopathologic findings confirmed histolytic necrotizing lymphadenitis (also called Kikuchi-Fujimoto disease), which can be induced by an infectious disease. Serum was sent to SYNLAB (Augsburg, Germany) for F. tularensis testing, and after 2 weeks, enzyme immunoassay showed increased IgM against F. tularensis (16.1 U/mL, cutoff<10 U/mL) but not IgG, which correlated with the clinical signs and indicated acute infection.
The patient was hospitalized for 2 weeks; she was febrile for 2 days (temperature not >39°C) and treated symptomatically. Ultrasonography for fetal anomaly performed at the Institute for Gynaecology and Obstetrics “Visegradska,” Belgrade, detected no abnormality, and fetal growth velocity was maintained. Blood analysis remained within reference limits, with no evidence of bacteremia. After receiving gentamicin (120 mg intramuscularly 1×/d) for 7 days, the patient was discharged at week 22 of gestation.
At term, the woman vaginally delivered a healthy boy, weighing 3,860 g, with Apgar scores of 9 at 1 minute and 10 at 5 minutes. Histopathologic examination of the placenta revealed no evidence of pathology. Newborn hearing screening on day 3 was normal bilaterally. At examinations performed 1 and 4 months after delivery, both mother and baby were healthy, with no complications, and all blood test results were within reference limits. The newborn was not tested further for infectious diseases.
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