ADMA/SDMA

The ADMA/SDMA test contains 1 test with 2 biomarkers.

Brief Description: The ADMA/SDMA test measures the levels of two specific molecules, asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA), in the blood. These molecules are naturally produced during protein breakdown and metabolism. The test is utilized to assess kidney function, cardiovascular health, and potential risks for various conditions.

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Collection Method: Blood Draw

Specimen Type: Serum

Test Preparation: No preparation required

When and Why the Test May Be Ordered:

An ADMA/SDMA test is ordered when there’s a suspicion of kidney dysfunction, especially when creatinine-based tests might not provide a complete picture. It’s also ordered to evaluate cardiovascular health, as elevated ADMA levels are associated with endothelial dysfunction and increased risk of heart disease. Individuals with risk factors like hypertension, diabetes, or a family history of heart disease may also undergo this test.

What the Test Checks For:

The ADMA/SDMA test primarily checks the levels of ADMA and SDMA in the blood. Elevated levels of ADMA are linked to reduced nitric oxide production, which can lead to impaired blood vessel function, contributing to conditions like hypertension and cardiovascular diseases. Elevated SDMA levels are often indicative of decreased kidney function.

Other Lab Tests That May Be Ordered Alongside:

When an ADMA/SDMA test is ordered, it’s often part of a broader evaluation of cardiovascular and kidney health. Here are some tests commonly ordered alongside it:

1. Lipid Profile:

   • Purpose: To measure levels of cholesterol and triglycerides.
   • Why Is It Ordered: To assess cardiovascular risk, as dyslipidemia is a major factor in heart disease and can be related to endothelial dysfunction.

2. Complete Blood Count (CBC):

   • Purpose: To evaluate overall blood health.
   • Why Is It Ordered: To assess for signs of anemia or other blood-related issues that can affect cardiovascular and overall health.

3. Kidney Function Test:

   • Purpose: To evaluate kidney function.
   • Why Is It Ordered: As SDMA is a marker for renal function, these tests can provide a comprehensive view of kidney health.

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   C-Reactive Protein (CRP) or High-Sensitivity CRP (hs-CRP):

   • Purpose: To detect inflammation.
   • Why Is It Ordered: Inflammatory processes can contribute to endothelial dysfunction and cardiovascular disease.

5. Fasting Blood Glucose and Hemoglobin A1c (HbA1c):

   • Purpose: To measure blood sugar control.
   • Why Is It Ordered: To assess for diabetes or prediabetes, conditions associated with endothelial dysfunction and cardiovascular risk.

6. Liver Function Test:

   • Purpose: To assess liver health.
   • Why Is It Ordered: Liver diseases can affect cardiovascular health and the metabolism of various substances including ADMA and SDMA.

7. Homocysteine:

   • Purpose: To measure the level of homocysteine, an amino acid linked to cardiovascular risk.
   • Why Is It Ordered: Elevated homocysteine can be associated with endothelial dysfunction and increased risk of cardiovascular diseases.

These tests, when ordered alongside an ADMA/SDMA test, provide a comprehensive view of cardiovascular and renal health. They are crucial for assessing the risk of heart disease, monitoring the health of the endothelium (the inner lining of blood vessels), and evaluating kidney function. The specific combination of tests will depend on the individual’s risk factors, symptoms, and medical history.

Conditions or Diseases Requiring the Test:

• Kidney Dysfunction: Elevated SDMA levels are associated with impaired kidney function, helping diagnose conditions like chronic kidney disease.
• Cardiovascular Diseases: Elevated ADMA levels are linked to endothelial dysfunction, hypertension, and increased cardiovascular risk.
• Diabetes: ADMA/SDMA tests might be ordered for diabetes patients due to the close link between diabetes, kidney health, and cardiovascular risks.

How Health Care Providers Use the Results:

• Diagnosis and Monitoring: The test helps diagnose kidney dysfunction and assess overall kidney health. It’s also used to gauge cardiovascular risk and monitor the effectiveness of treatments aimed at improving kidney and cardiovascular health.
• Treatment Planning: Results guide healthcare providers in developing treatment plans tailored to the patient’s individual risks and needs.
• Prevention: In individuals at risk of developing kidney disease or cardiovascular issues, the test can aid in preventive measures and lifestyle adjustments.

In conclusion, the ADMA/SDMA test is a crucial tool for evaluating kidney function and cardiovascular health. By measuring the levels of ADMA and SDMA, healthcare providers can diagnose conditions, assess risks, and design effective treatment plans. This test plays a significant role in maintaining the well-being of patients by allowing early detection and management of kidney and cardiovascular-related issues.

Most Common Questions About the ADMA/SDMA test:

Understanding the Test and Its Clinical Application

What is the ADMA/SDMA test, and what is its purpose?

The ADMA/SDMA test measures the levels of Asymmetric Dimethylarginine (ADMA) and Symmetric Dimethylarginine (SDMA) in the blood. These biomarkers are associated with nitric oxide synthesis and have been implicated in cardiovascular diseases, renal dysfunction, and other conditions. The test can help in early detection, monitoring, and understanding the underlying pathophysiology of such diseases.

How do ADMA and SDMA levels relate to cardiovascular diseases?

Elevated levels of ADMA inhibit nitric oxide synthase, which reduces nitric oxide production. Since nitric oxide is crucial for vasodilation, elevated ADMA levels can lead to endothelial dysfunction and contribute to cardiovascular diseases. SDMA doesn’t directly inhibit nitric oxide synthesis but may indicate renal dysfunction, another risk factor for cardiovascular diseases.

Clinical Significance and Diagnosis

What diseases can be diagnosed or monitored using the ADMA/SDMA test?

The ADMA/SDMA test can be used in diagnosing and monitoring cardiovascular diseases like atherosclerosis, hypertension, heart failure, and chronic kidney disease (CKD). Elevated levels of ADMA and SDMA may be indicative of endothelial dysfunction, increased cardiovascular risk, and renal impairment.

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How does the ADMA/SDMA test aid in the assessment of renal function?

SDMA, in particular, is considered a sensitive marker for renal function. It is less influenced by non-renal factors compared to other kidney function markers like creatinine. The ADMA/SDMA test can help in early detection of renal dysfunction, which is especially relevant for patients with diabetes or other conditions predisposing them to kidney disease.

Interpreting Test Results

What are the normal reference ranges for the ADMA/SDMA test?

The clinical reference ranges are:

• ADMA: less than 100 ng/mL
• SDMA: 73 to 135 ng/mL

Understanding these values in the context of other clinical information and patient history is essential for accurate interpretation.

How are abnormal results in the ADMA/SDMA test interpreted?

Elevated ADMA levels are usually associated with reduced nitric oxide synthesis and may indicate a higher risk for cardiovascular diseases. High SDMA levels might suggest renal dysfunction. Interpreting these results requires considering other clinical factors, laboratory findings, and patient history to derive meaningful insights.

Integration with Other Diagnostic Tools

How does the ADMA/SDMA test complement other cardiovascular risk assessments?

The ADMA/SDMA test adds value to other cardiovascular risk assessments by providing insights into nitric oxide metabolism and renal function. When combined with traditional risk factors and other biomarkers, it offers a more nuanced understanding of an individual’s cardiovascular risk profile.

Can the ADMA/SDMA test be used in conjunction with renal function tests like creatinine?

Yes, the ADMA/SDMA test can complement traditional renal function tests like creatinine and eGFR. SDMA is often considered a more sensitive marker, especially in early stages of renal impairment, and can provide additional information to guide diagnosis and treatment.

We advise having your results reviewed by a licensed medical healthcare professional for proper interpretation of your results.

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