Keppra (Levetiracetam)

How do you take Keppra?

Keppra is available in several forms:

• Tablets (immediate release): 250mg, 500mg, 750mg, and 1000mg.

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• Tablets (extended release): 500mg and 750mg.

• Liquid solution: 100mg/ml.

• Injection solution: 5mg/ml, 10mg/ml, 15mg/ml, and 100 mg/ml.

Read the Patient Information Leaflet provided by your pharmacist before starting levetiracetam. If you have any further concerns or questions, ask your healthcare provider.

Take the medication as directed by your doctor, twice daily with or without meals.

Liquid form

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If you’re using the liquid form of the medicine, carefully measure the dose by using a medical measuring device. For example, use the measuring cup that comes with the medication instead of a household spoon. Using the right tool means you’ll get the correct amount and avoid any symptoms reappearing.

Tablet form

Take this drug as instructed by your healthcare provider, usually once daily.

Do not break or chew Keppra pills. This can create a bitter taste and affect how your body processes the medicine. This can increase the risks of side effects. Don’t split tablets if they don’t have a score line unless your doctor or pharmacist tells you to.

Your doctor bases the dose on your medical condition and how your body responds to treatment. The dosage in children depends on their weight. To lessen the chances of side effects, your doctor may suggest starting this medication at a low dosage and gradually increasing your dosage. Follow their directions carefully.

For liquid injection

The dose is 100mg per 1mL (milliliters). In 2006, the FDA approved Keppra as an alternative for patients with seizures who cannot take their medicine orally.

It must be diluted before use according to the package insert and administered as a 15-minute intravenous (IV) infusion.

Daily dose for juvenile myoclonic epilepsy

Your doctor will start treatment with a dose of 1000mg per day (500mg twice daily) for the first week. Increase the dosage by 1000mg per day every two weeks to the recommended daily dosage of 3000mg. Researchers have not studied the effectiveness of doses below 3000mg per day.

Daily dosage for primary generalized tonic-clonic seizures

For adolescents and adults aged 16 years and older

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Your doctor will start treatment with a dose of 1000mg per day (as 500mg twice daily) for the first week. Increase the dosage by 1000mg per day every two weeks to the recommended daily dosage of 3000mg. Researchers have not studied the effectiveness of doses above 3000mg per day.

For pediatric patients aged 6 to 16 years

Your doctor will start treatment with a daily dose between 20 and 30mg/kg in two equally divided doses. Increase the daily dose of the medication every two weeks by increments of 10mg/kg (5mg/kg twice daily) until the recommended daily dose of 30mg/kg (15mg/kg twice daily is reached). There are no adequate studies on the effectiveness of doses lower than 30mg/kg per day.

Daily dosage for partial-onset seizures

For adolescents and adults aged 16 years and older

Your doctor will start treatment with a dose of 1000mg per day (as 500mg twice daily) for the first week. Your doctor may give additional doses up to 1000mg per day to the maximum recommended daily dosage of 3000mg. Researchers have not studied the effectiveness of doses below 3000mg per day.

For pediatric patients from 1-6 months

Your doctor will start treatment at a dose of 7mg/kg twice daily. Increase the daily dose by increments every two weeks until you reach the recommended daily dose (21mg/kg twice daily).

For pediatric patients aged six months to under four years

Your doctor will start treatment with a daily dose equal to 20mg/kg divided into two 10mg/kg doses twice daily. They will increase the daily dose by 20mg/kg every two weeks until reaching the recommended daily dose of 50mg/kg (25mg/kg twice daily). If your child cannot tolerate 25mg/kg, your doctor may reduce the daily dosage.

Take this medication regularly to get the maximum benefit from it. To help you remember better, take it at the same time every day.

You may need to give your child levetiracetam (Keppra) for several weeks before you see a decrease in seizures. If there is no decrease after two weeks, contact your healthcare provider.

Do not increase your dosage or use this drug more frequently than prescribed. Your condition will not improve any faster, and your chances of experiencing side effects of levetiracetam will increase.

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