The 11 Best Anti-Itch Creams, Tested by Our Editors

Is there anything more frustrating than dealing with an itch you can’t seem to get rid of? We think not. Thankfully, there are a plethora of anti-itch creams on the market that address all types of itchiness. Anti-itch creams use different ingredients, textures, and applications to help relieve itchiness and soothe irritated skin.

When looking for an anti-itch cream, look for specific ingredients like hydrocortisone, antihistamines, numbing agents (think pramoxine hydrochloride and lidocaine), and colloidal oatmeal. You also want to consider different application methods (sprays are great for things like poison ivy, while ointments work well for bug bites) and the severity of your symptoms (steroid creams work well for more severe itchiness).

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We tested multiple anti-itch creams to evaluate which products are best for which types of itch. We considered, tested, and awarded them for their effectiveness, feel, texture, and value. Then, we had a dermatologist from our Medical Expert Board review this article for medical and scientific accuracy.

Our Top Picks

• Best Overall: Sarna Anti-Itch Lotion
• Best for Eczema: Curél Hydratherapy Itch Defense Wet Skin Moisturizer
• Best for Poison Ivy or Rashes: Benadryl Itch Cooling Spray
• Best for Psoriasis: Aveeno Anti-Itch Cream
• Best for Body Lotion: Gold Bond Medicated Anti-Itch Lotion
• Best for Sensitive Skin: Vanicream Moisturizing Lotion
• Best Spot Treatment: Campho-Phenique Maximum Strength Antiseptic Gel
• Best for Eczema: Aveeno Itch Relief Balm
• Best Hydrocortisone: Cortizone 10 1% Hydrocortisone Anti-Itch Cream
• Best for Face: La Roche-Posay Lipikar AP+M Triple Repair Body Cream

Ingredients to Look for in Anti-Itch Cream

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Dealing with itchy skin can be a nuisance, but thankfully, there are tons of ingredients available to treat and prevent itchiness. These include:

• Hydrocortisone: This is a steroid that calms your body’s inflammatory response, which will help quell itching, swelling, and pain.
• Antihistamines: These include ingredients like diphenhydramine and cetirizine. These are usually taken orally but can sometimes be found in topicals. They work by blocking histamines, the substances released by your immune system in reaction to an allergen.
• Numbing agents: Pramoxine hydrochloride and lidocaine can temporarily numb the skin to which they’ve been applied, helping to relieve some of that prickly and irritating sensation caused by itching, according to Geeta Yadav, MD, a board-certified dermatologist and founder of FACET Dermatology. If you’ve ever gotten a bad sunburn and used aloe, you might have used a formula that contained lidocaine.
• Colloidal Oatmeal: According to Dr. Yadav, colloidal oats are one of the best ingredients for relieving itchy skin. This natural ingredient draws and seals moisture into the skin and helps soothe discomfort, which is why you’ll find it in many remedies for eczema.
• Ceramides: These can also help repair the skin barrier and help patients with dry and sensitive skin.
• Antifungals: If the source of your itch is due to a fungal infection like ringworm or athlete’s foot, you’ll want to use an antifungal ingredient, such as clotrimazole, to get to the root of the issue rather than temporarily treat the itch.

What to Avoid

Anti-itch products might contain ingredients that provide a cooling sensation to help create a sense of relief. Some, like aloe, are pretty harmless, but others, like menthol and camphor, could potentially be irritating. Alcohol and witch hazel fall into a category of ingredients that can strip the skin, and Dr. Yadav recommends avoiding fragrance whenever possible. If your skin is itchy due to eczema, fragrances and dyes are common triggers of this condition, and avoiding them can help significantly reduce your risk of a flare-up.

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