Blood tests which display levels of biomarkers – measurable units, such as cholesterol or glucose levels, that indicate the efficacy of biological functions – can help us understand the inner workings of our bodies to improve health, prevent disease, and understand the impact of lifestyle choices.
One of the areas in which biomarkers have already made an impact is in personalized medicine. This modern approach to health is especially important for females. Many research studies and trials that helped develop successful treatments and surgeries were predominantly tested on male participants.
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Often, we don’t know if these treatments are actually well-adapted to females. The only way to truly know is through a personalized approach. For a better understanding of female health, it’s essential to be aware that some blood tests can be different for each sex.
Besides the fact that females have different reference ranges (expected ranges of values for a healthy population), female hormones can also influence lab results. Research shows that concentrations of various hormones fluctuating throughout the menstrual cycle may have significant effects on levels of biomarkers including iron, lipids, thyroid hormones, insulin, blood glucose, and more.
How your menstrual cycle works
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Your menstrual cycle affects many processes in your body. Throughout your cycle, your hormone levels rise and fall, affecting your blood test results. To understand how this works, it’s essential to understand what goes on in your body during your menstrual cycle.
Menstrual cycle phases
Your menstrual cycle happens in four phases. They are:
- Menstruation: During menstruation, your uterus lining sheds and leaves your body through your vagina.
- Follicular phase: The follicular phase co-occurs with your menstruation. It begins on the first day of your period and ends when your ovulation begins. During this phase, your brain signals your pituitary gland to release the follicle-stimulating hormone (FSH). The hormone causes your ovaries to produce small follicles. Each follicle contains an immature egg and one egg will develop.
- Ovulation: The egg developed during your follicular phase is released during ovulation. The luteinizing hormone (LH) stimulates this process.
- Luteal phase: During this stage, the follicle that released your egg transforms into the corpus luteum, the function of which is to release progesterone. Progesterone helps keep the walls of your uterus thick and prepared for the implantation of a fertilized egg. You’re likely to experience PMS symptoms like mood swings, bloating, headaches, tender breasts, and food cravings during the luteal phase.
If your egg isn’t fertilized during the luteal phase, your body absorbs it, your estrogen and progesterone levels drop, and your cycle starts all over again.
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