Zejula is a brand-name prescription drug. It’s FDA-approved for use in adults to treat certain cancers that affect the ovaries, fallopian tubes, or peritoneum. (The peritoneum is a thin layer of tissue that lines the inside of your belly.)
Specifically, Zejula is approved to treat the following forms of ovarian cancer:*
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- Advanced ovarian cancer. With advanced ovarian cancer, the cancer has spread out of the ovaries. For this use, Zejula is given as a first-choice maintenance treatment. As a maintenance treatment, Zejula is used after your cancer has first been treated with other therapy. Specifically, Zejula is used in people whose cancer disappeared, either partly or completely, after treatment with chemotherapy that’s made with platinum. (Chemotherapy describes traditional drugs used to treat cancer.)
- Recurrent ovarian cancer. With recurrent cancer, the cancer improved with past treatment, but it has come back. For this use, Zejula is given as a maintenance treatment. And it’s used in people whose ovarian cancer disappeared, either partly or completely, after treatment with chemotherapy that’s made with platinum.
- Advanced ovarian cancer that’s already been treated with three or more chemotherapy regimens. For this use, Zejula is given to people whose cancer is related to a genetic mutation (abnormal gene change) called homologous recombination deficiency (HRD).
* Certain cancers in the fallopian tubes and peritoneum can be so similar to ovarian cancer that they’re sometimes labeled as ovarian cancer. In this article, cancer of the ovaries, fallopian tubes, and peritoneum are all referred to as “ovarian cancer.”
Drug form, administration, and active ingredient
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Zejula comes as capsules that are taken by mouth. It contains the active drug niraparib.
Niraparib belongs to a class of drugs called poly (ADP-ribose) polymerase (PARP) inhibitors. A drug class describes a group of medications that work in a similar way.
FDA approval
In 2017, the Food and Drug Administration (FDA) approved Zejula for maintenance treatment of recurrent ovarian cancer. Zejula was the first PARP drug approved for ovarian cancer that has responded to chemotherapy that’s made with platinum.
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Then, in 2020, the FDA expanded Zejula’s approval to include treatment of advanced ovarian cancer that’s already been treated with three or more chemotherapy regimens.
Effectiveness
In clinical studies, Zejula was effective as a maintenance treatment for recurrent ovarian cancer.
In other clinical studies, Zejula was also effective in treating advanced ovarian cancer. The drug was effective as a maintenance therapy after one round of chemotherapy, and in treating advanced ovarian cancer that had already been treated with three or more chemotherapy regimens.
For more information on Zejula’s effectiveness, see the “Zejula uses” section below.
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