Trazodone is an atypical antidepressant that is frequently prescribed off-label for insomnia due to its sedating effect. It is most commonly sold under the brand name Desyrel. The medication works mainly by modulating different serotonin receptors. It also blocks alpha-adrenergic receptors and has a mild effect on H1 receptors.One common side effect of Trazodone is nasal congestion, also known as a stuffy nose. It’s estimated that 1-10% of patients taking the medication experience this problem, which may be even more pronounced during nighttime. This may negate any perceived sleep improvements from the medication or worsen any preexisting difficulties.
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Why Does Trazodone Cause a Stuffy Nose?
The exact reason why Trazodone can cause a stuffy nose is not exactly clear. However, it may be attributed to Trazodone’s effect in blocking the adrenergic receptors of the brain, causing relaxation in the blood vessels of the nasal mucosa. This leads to increased local blood flow, which can cause the mucosa in the nose to swell. As a result, the nose becomes congested and sufficient air can’t pass through the nasal airways. This is perceived as a stuffy nose.
Treatment and Other Options
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Experiencing a stuffy nose as a side effect of Trazodone can be bothersome, especially for individuals already struggling with insomnia, restless nights, and difficulties falling asleep. Like insomnia, research has shown that nasal congestion can significantly affect the quality of life.Ensure that the nasal congestion isn’t stemming from any underlying cause, other than the medication, before making any changes to your medical routine. This may include allergies, upper respiratory tract infections, and gastrointestinal reflux. Consult your doctor for help.
1. Nasal Decongestants
As opposed to Trazodone, which works by blocking alpha-adrenergic receptors and causing nasal mucous swelling, other medications can locally activate these same receptors, leading to a less stuffy nose. These medications are known as nasal decongestants, such as nose sprays containing Xylometazoline. Although nasal decongestants can provide immediate relief, prolonged use exceeding 3-5 days can worsen the nasal congestion instead of alleviating it. As such, it can only be used to alleviate the stuffy nose from Trazodone during the first few days.
2. Saline Nose Sprays
Saline nose sprays are generally non-medicated. Instead, they only contain water and salt. They are designed to address dryness within the nasal passages, providing moisture to dissolve and soften thick or crusty mucus. Use the saline spray before bed and at night if you wake up.
3. Sleep in an Elevated Position
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Sleeping in a supine position naturally leads to increased swelling of the nasal mucosa due to gravity. To alleviate this, consider sleeping in an elevated position. This not only helps keep all the upper airways open, but it also facilitates easier breathing overall. Moreover, does it help reduce snoring, which can be caused by a stuffy nose.
4. Drink Plenty of Water
Stay hydrated by drinking plenty of water. This helps reduce nasal irritation and keeps mucus thin, making it easier to clear by blowing your nose. Healthy adults living in moderate climates should aim for around 15.5 cups (3.7 liters) of fluids per day for men and about 11.5 cups (2.7 liters) for women. Avoid drinking water half an hour before bedtime as it can lead to waking up during the night and having to go to the toilet.
5. Change Medication
If your stuffy nose persists for more than 2 weeks despite trying the remedies mentioned earlier, you should consult your prescribing physician about treatment options other than Trazodone. They can explore different medications that are suitable to your specific needs, whether it’s for managing depression, insomnia, or any other underlying condition. Learn more about antidepressants that can help with insomnia.
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