ASPARTIC ACID – Uses, Side Effects, and More

Abel, T., Knechtle, B., Perret, C., Eser, P., von Arx, P., and Knecht, H. Influence of chronic supplementation of arginine aspartate in endurance athletes on performance and substrate metabolism – a randomized, double-blind, placebo-controlled study. Int J Sports Med 2005;26(5):344-349. View abstract.

Colombani, P. C., Bitzi, R., Frey-Rindova, P., Frey, W., Arnold, M., Langhans, W., and Wenk, C. Chronic arginine aspartate supplementation in runners reduces total plasma amino acid level at rest and during a marathon run. Eur J Nutr. 1999;38(6):263-270. View abstract.

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Denis, C., Dormois, D., Linossier, M. T., Eychenne, J. L., Hauseux, P., and Lacour, J. R. Effect of arginine aspartate on the exercise-induced hyperammoniemia in humans: a two periods cross-over trial. Arch.Int Physiol Biochim.Biophys. 1991;99(1):123-127. View abstract.

FORMICA, P. E. The housewife syndrome. Treatment with the potassium and magnesium salts of aspartic acid. Curr.Ther.Res.Clin.Exp. 1962;4:98-106. View abstract.

HICKS, J. T. TREATMENT OF FATIGUE IN GENERAL PRACTICE: A DOUBLE BLIND STUDY. Clin.Med (Northfield.Il) 1964;71:85-90. View abstract.

NAGLE, F. J., BALKE, B., GANSLEN, R. V., and DAVIS, A. W., Jr. THE MITIGATION OF PHYSICAL FATIGUE WITH “SPARTASE”. REP 63-12. Rep.Civ.Aeromed.Res.Inst.US. 1963;1-10. View abstract.

Ruddel, H., Werner, C., and Ising, H. Impact of magnesium supplementation on performance data in young swimmers. Magnes.Res 1990;3(2):103-107. View abstract.

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SHAW, D. L., Jr., CHESNEY, M. A., TULLIS, I. F., and AGERSBORG, H. P. Management of fatigue: a physiologic approach. Am.J Med Sci. 1962;243:758-769. View abstract.

Trudeau, F. Aspartate and its ergogenic potential. Science & Sports 1996;11(4):223-232.

Tuttle, J. L., Potteiger, J. A., Evans, B. W., and Ozmun, J. C. Effect of acute potassium-magnesium aspartate supplementation on ammonia concentrations during and after resistance training. Int J Sport Nutr. 1995;5(2):102-109. View abstract.

Beltz SD, Doering PL. Efficacy of nutritional supplements used by athletes. Clin Pharm 1993;12:900-8. View abstract.

Firoz M, Graber M. Bioavailability of US commercial magnesium preparations. Magnes Res 2001;14:257-62.. View abstract.

Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: The National Academies Press, 2005. Available at: https://doi.org/10.17226/10490

Ichikawa S, Gohda T, Murakoshi M, et al. Aspartic acid supplementation ameliorates symptoms of diabetic kidney disease in mice. FEBS Open Bio. 2020;10(6):1122-34. View abstract.

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Karras SN, Koufakis T, Dimakopoulos G, Popovic DS, Kotsa K. Changes in dietary intake of aspartic acid during and after intermittent fasting correlate with an improvement in fasting glucose in overweight individuals. J Diabetes 2023;15(2):181-184. View abstract.

Melville GW, Siegler JC, Marshall PWM. The effects of d-aspartic acid supplementation in resistance-trained men over a three month training period: A randomised controlled trial. PLoS One. 2017;12(8):e0182630. View abstract.

Ota N, Shi T, Sweedler JV. D-Aspartate acts as a signaling molecule in nervous and neuroendocrine systems. Amino Acids 2012;43:1873-86. View abstract.

Roshanzamir F, Safavi SM. The putative effects of D-Aspartic acid on blood testosterone levels: a systematic review. Int J Reprod Biomed (Yazd) 2017;15:1-10.View abstract.

Umeda K, Shindo D, Somekawa S, et al. Effects of Five Amino Acids (Serine, Alanine, Glutamate, Aspartate, and Tyrosine) on Mental Health in Healthy Office Workers: A Randomized, Double-Blind, Placebo-Controlled Exploratory Trial. Nutrients 2022;14(11):2357. View abstract.

Wagenmakers A. Muscle amino acid metabolism at rest and during exercise: role in human physiology and metabolism. Exerc Sport Sci Rev 1998;26:287-314. View abstract.

Willoughby DS, Leutholtz B. D-aspartic acid supplementation combined with 28 days of heavy resistance training has no effect on body composition, muscle strength, and serum hormones associated with the hypothalamo-pituitary-gonadal axis in resistance-trained men. Nutr Res 2013;33:803-10. View abstract.

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