PRICKLY PEAR CACTUS – Uses, Side Effects, and More

Bouslama, L., Hayashi, K., Lee, J. B., Ghorbel, A., and Hayashi, T. Potent virucidal effect of pheophorbide a and pyropheophorbide a on enveloped viruses. J.Nat.Med. 2011;65(1):229-233. View abstract.

Budinsky, A., Wolfram, R., Oguogho, A., Efthimiou, Y., Stamatopoulos, Y., and Sinzinger, H. Regular ingestion of opuntia robusta lowers oxidation injury. Prostaglandins Leukot.Essent.Fatty Acids 2001;65(1):45-50. View abstract.

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de, Wit M., Nel, P., Osthoff, G., and Labuschagne, M. T. The effect of variety and location on cactus pear (Opuntia ficus-indica) fruit quality. Plant Foods Hum.Nutr. 2010;65(2):136-145. View abstract.

Ennouri, M., Fetoui, H., Bourret, E., Zeghal, N., and Attia, H. Evaluation of some biological parameters of Opuntia ficus indica. 1. Influence of a seed oil supplemented diet on rats. Bioresour.Technol. 2006;97(12):1382-1386. View abstract.

Ennouri, M., Fetoui, H., Bourret, E., Zeghal, N., Guermazi, F., and Attia, H. Evaluation of some biological parameters of Opuntia ficus indica. 2. Influence of seed supplemented diet on rats. Bioresour.Technol. 2006;97(16):2136-2140. View abstract.

Fernandez, M. L., Lin, E. C., Trejo, A., and McNamara, D. J. Prickly pear (Opuntia sp.) pectin reverses low density lipoprotein receptor suppression induced by a hypercholesterolemic diet in guinea pigs. J Nutr 1992;122(12):2330-2340. View abstract.

Fernandez, M. L., Trejo, A., and McNamara, D. J. Pectin isolated from prickly pear (Opuntia sp.) modifies low density lipoprotein metabolism in cholesterol-fed guinea pigs. J Nutr 1990;120(11):1283-1290. View abstract.

Frati AC, Jimenex E Aruza R. Hypoglycemic effect of Opuntia ficus indica in non-insulin dependent diabetes mellitus patients. Phytother Res 1990;4(5):195-197.

Frati, A. C., Gordillo, B. E., Altamirano, P., Ariza, C. R., Cortes-Franco, R., Chavez-Negrete, A., and Islas-Andrade, S. Influence of nopal intake upon fasting glycemia in type II diabetics and healthy subjects. Arch Invest Med (Mex.) 1991;22(1):51-56. View abstract.

Frati-Munari, A. C., de Leon, C., Ariza-Andraca, R., Banales-Ham, M. B., Lopez-Ledesma, R., and Lozoya, X. [Effect of a dehydrated extract of nopal (Opuntia ficus indica Mill.) on blood glucose]. Arch.Invest Med.(Mex.) 1989;20(3):211-216. View abstract.

Frati-Munari, A. C., Fernandez-Harp, J. A., Banales-Ham, M., and Ariza-Andraca, C. R. Decreased blood glucose and insulin by nopal (Opuntia sp.). Arch Invest Med (Mex.) 1983;14(3):269-274. View abstract.

Frati-Munari, A. C., Fernandez-Harp, J. A., de la, Riva H., Ariza-Andraca, R., and del Carmen, Torres M. Effects of nopal (Opuntia sp.) on serum lipids, glycemia and body weight. Arch Invest Med (Mex.) 1983;14(2):117-125. View abstract.

Frati-Munari, A. C., Rios, Gil U., Ariza-Andraca, C. R., Islas, Andrade S., and Lopez, Ledesma R. [Duration of the hypoglycemic action of Opuntia streptacantha Lem.]. Arch Invest Med (Mex.) 1989;20(4):297-300. View abstract.

Galati, E. M., Mondello, M. R., Lauriano, E. R., Taviano, M. F., Galluzzo, M., and Miceli, N. Opuntia ficus indica (L.) Mill. fruit juice protects liver from carbon tetrachloride-induced injury. Phytother Res 2005;19(9):796-800. View abstract.

Godard, M. P., Ewing, B. A., Pischel, I., Ziegler, A., Benedek, B., and Feistel, B. Acute blood glucose lowering effects and long-term safety of OpunDia supplementation in pre-diabetic males and females. J.Ethnopharmacol. 8-9-2010;130(3):631-634. View abstract.

Kleiner, O., Cohen, Z., and Mares, A. J. Low colonic obstruction due to Opuntia ficus indica seeds: the aftermath of enjoying delicious cactus fruits. Acta Paediatr. 2002;91(5):606-607. View abstract.

Laurenz, J. C., Collier, C. C., and Kuti, J. O. Hypoglycaemic effect of Opuntia lindheimeri Englem in a diabetic pig model. Phytother Res 2003;17(1):26-29. View abstract.

Li, C. Y., Cheng, X. S., Cui, M. Z., and Yan, Y. G. [Regulative effect of Opuntia powder on blood lipids in rats and its mechanism]. Zhongguo Zhong.Yao Za Zhi. 2005;30(9):694-696. View abstract.

Lim, K. T. Inhibitory effect of glycoprotein isolated from Opuntia ficus-indica var. saboten MAKINO on activities of allergy-mediators in compound 48/80-stimulated mast cells. Cell Immunol. 2010;264(1):78-85. View abstract.

Linares, E., Thimonier, C., and Degre, M. The effect of NeOpuntia on blood lipid parameters-risk factors for the metabolic syndrome (syndrome X). Adv.Ther. 2007;24(5):1115-1125. View abstract.

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Meckes-Lozyoa, M. and Roman-Ramos, R. Opuntia streptacantha: a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14(3-4):116-118. View abstract.

Palumbo, B., Efthimiou, Y., Stamatopoulos, J., Oguogho, A., Budinsky, A., Palumbo, R., and Sinzinger, H. Prickly pear induces upregulation of liver LDL binding in familial heterozygous hypercholesterolemia. Nucl.Med Rev Cent.East Eur 2003;6(1):35-39. View abstract.

Pittler, M. H., Verster, J. C., and Ernst, E. Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials. BMJ 12-24-2005;331(7531):1515-1518. View abstract.

Sanchez, E., Garcia, S., and Heredia, N. Extracts of edible and medicinal plants damage membranes of Vibrio cholerae. Appl.Environ.Microbiol. 2010;76(20):6888-6894. View abstract.

Steinberg, J. M. and Eitan, A. Prickly pear fruit bezoar presenting as rectal perforation in an elderly patient. Int J Colorectal Dis. 2003;18(4):365-367. View abstract.

Tesoriere L, Allegra M Butera D et al. Absorption, excretion, and distribution of dietary antioxidant betalains in LDLs: Potential health effects of betalains in humans. Am J Clin Nutr 2004;80:941-945.

Wolfram, R. M., Kritz, H., Efthimiou, Y., Stomatopoulos, J., and Sinzinger, H. Effect of prickly pear (Opuntia robusta) on glucose- and lipid-metabolism in non-diabetics with hyperlipidemia-a pilot study. Wien.Klin.Wochenschr. 10-31-2002;114(19-20):840-846. View abstract.

Ahmad A, Davies J, Randall S, Skinner GR. Antiviral properties of extract of Opuntia streptacantha. Antiviral Res 1996;30:75-85. View abstract.

Akacha A, Rebai T, Zourgui L, Amri M. Preventive effect of ethanolic extract of cactus (Opuntia ficus-indica) cladodes on methotrexate-induced oxidative damage of the small intestine in Wistar rats. J Cancer Res Ther. 2018;14(Supplement):S779-84. doi: 10.4103/0973-1482.174555. View abstract.

Argaez-Lopez N, Wacher NH, Kumate-Rodriguez J, et al. The use of complementary and alternative medicine therapies in type 2 diabetic patients in Mexico. Diabetes Care 2003;26:2470-1. View abstract.

Bacardi-Gascon M, Duenas-Mena D, Jimenez-Cruz A. Lowering effect on postprandial glycemic response of nopales added to Mexican breakfasts. Diabetes Care 2007;30:1264-5. View abstract.

Bush TM, Rayburn KS, Holloway SW, et al. Adverse interactions between herbal and dietary substances and prescription medications: a clinical survey. Altern Ther Health Med 2007;13:30-5. View abstract.

Cárdenas Y, Ríos-Silva M, Huerta M, et al. The comparative effect of nopal and mucilage in metabolic parameters in rats with a high-fructose diet. J Med Food 2019;22(5):538-41. doi: 10.1089/jmf.2018.0124. View abstract.

De Santiago E, Gill CIR, Carafa I, Tuohy KM, De Peña MP, Cid C. Digestion and colonic fermentation of raw and cooked Opuntia ficus-indica cladodes impacts bioaccessibility and bioactivity. J Agric Food Chem 2019;67(9):2490-9. doi: 10.1021/acs.jafc.8b06480. View abstract.

Fernandez ML, Lin EC, Trejo A, McNamara DJ. Prickly pear (Opuntia sp.) pectin alters hepatic cholesterol metabolism without affecting cholesterol absorption in guinea pigs fed a hypercholesterolemic diet. J Nutr 1994;124:817-24. View abstract.

Frati AC, Xilotl Diaz N, Altamirano P, et al. The effect of two sequential doses of Opuntia streptacantha upon glycemia. Arch Invest Med (Mex) 1991;22:333-6. View abstract.

Frati Munari AC, Quiroz Lazaro JL, Alramirano Bustamante P, et al. The effect of various doses of nopal (Opuntia streptacantha Lemaire) on the glucose tolerance test in healthy individuals. Arch Invest Med (Mex) 1988;19:143-8.

Frati Munari AC, Vera Lastra O, Ariza Andraca CR. Evaluation of nopol capsules in diabetes mellitus. Gac Med Mex 1992;128:431-6. View abstract.

Frati-Munari AC, Altamirano-Bustamante E, Rodríguez-Bárcenas N, et al. Hypoglycemic action of Opuntia streptacantha Lemaire: study using raw extracts. Arch Invest Med (Mex) 1989;20:321-5. View abstract.

Frati-Munari AC, Del Valle-Martinez LM, Ariza-Andraca CR, et al. Hypoglycemic action of different doses of nopal (Opuntia streptacantha Lemaire) in patients with type II diabetes mellitus. Arch Invest Med (Mex) 1989;20:197-201. View abstract.

Frati-Munari AC, Gordillo BE, Altamirano P, Ariza CR. Hypoglycemic effect of Opuntia streptacantha Lemaire in NIDDM. Diabetes Care 1988;11:63-6. View abstract.

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Frati-Munari AC, Licona-Quesada R, Araiza-Andraca CR, et al. Activity of Opuntia streptocantha in healthy individuals with induced hyperglycemia. Arch Invest Med (Mex) 1990;21:99-102. View abstract.

Frati-Munari AC, Roca-Vides RA, Lopez-Perez RJ, et al. The glycemic index of some foods common in Mexico. Gac Med Mex 1991;127:163-70. View abstract.

Gambino G, Brighina F, Allegra M, et al. Modulation of Human Motor Cortical Excitability and Plasticity by Opuntia Ficus Indica Fruit Consumption: Evidence from a Preliminary Study through Non-Invasive Brain Stimulation. Nutrients 2022;14(22):4915. View abstract.

Giglio RV, Carruba G, Cicero AFG, et al. Pasta Supplemented with Opuntia ficus-indica Extract Improves Metabolic Parameters and Reduces Atherogenic Small Dense Low-Density Lipoproteins in Patients with Risk Factors for the Metabolic Syndrome: A Four-Week Intervention Study. Metabolites 2020;10(11):428. View abstract.

Han EH, Lim MK, Lee S, et al. Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55-85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study. J Med Food 2020;23(11):1146-1154. View abstract.

Jeong H, Kim S, Kim MY, et al. Inhibitory and inductive effects of Opuntia ficus indica extract and its flavonoid constituents on cytochrome P450s and UDP-glucuronosyltransferases. Int J Mol Sci 2018;19(11):3400. doi: 10.3390/ijms19113400. View abstract.

López-Romero P, Pichardo-Ontiveros E, Avila-Nava A, Vázquez-Manjarrez N, Tovar AR, Pedraza-Chaverri J, et al. The effect of Nopal (Opuntia Ficus Indica) on postprandial blood glucose, incretins, and antioxidant activity in Mexican patients with type 2 diabetes after consumption of two different composition breakfasts. J Acad Nutr Diet. 2014;114(11):1811-8. View abstract.

Malfa GA, Di Giacomo C, Cardia L, Sorbara EE, Mannucci C, Calapai G. A standardized extract of Opuntia ficus-indica (L.) Mill and Olea europaea L. improves gastrointestinal discomfort: A double-blinded randomized-controlled study. Phytother Res 2021;35(7):3756-3768. View abstract.

Meckes-Lozyoa M, Roman-Ramos R. Opuntia streptacantha; a coadjutor in the treatment of diabetes mellitus. Am J Chin Med 1986;14:116-8.

Newcomer AD, Park HS, O’Brien PC, McGill DB. Response of patients with irritable bowel syndrome and lactase deficiency using unfermented acidophilus milk. Am J Clin Nutr 1983;38:257-63. View abstract.

Onakpoya IJ, O’Sullivan J, Heneghan CJ. The effect of cactus pear (Opuntia ficus-indica) on body weight and cardiovascular risk factors: a systematic review and meta-analysis of randomized clinical trials. Nutrition. 2015;31(5):640-6. View abstract.

Palevitch D, Earon G, Levin I. Treatment of benign prostatic hypertrophy with Opuntia ficus-indica (L.) Miller. Int J Comp Alt Med 1994;Sept:21-2.

Preen D, Dawson B, Goodman C, et al. Effect of creatine loading on long-term sprint exercise performance and metabolism. Med Sci Sports Exerc 2001;33:814-21. View abstract.

Rayburn K, Martinez R, Escobedo M, et al. Glycemic effects of various species of nopal (Opuntia sp.) in type 2 diabetes mellitus. Texas J Rural Health 1998;26:68-76.

Roman-Ramos R, Flores-Saenz JL, Alarcon-Aguilar FJ. Anti-hyperglycemic effect of some edible plants. J Ethnopharmacol 1995;48:25-32. View abstract.

Roman-Ramos R, Flores-Saenz JL, Partida-Hernandez G, et al. Experimental study of the hypoglycemic effect of some antidiabetic plants. Arch Invest Med (Mex) 1991;22:87-93. View abstract.

Sobieraj DM, Freyer CW. Probable hypoglycemic adverse drug reaction associated with prickly pear cactus, glipizide, and metformin in a patient with type 2 diabetes mellitus. Ann Pharmacother 2010;44:1334-7. View abstract.

Tesoriere L, Butera D, Pintaudi AM, et al. Supplementation with cactus pear (Opuntia ficus-indica) fruit decreases oxidative stress in healthy humans: a comparative study with vitamin C. Am J Clin Nutr 2004;80:391-5. View abstract.

Trejo-Gonzalez A, Gabriel-Ortiz G, Puebla-Perez A, et al. A purified extract from prickly pear cactus (Opuntia fuliginosa) controls experimentally induced diabetes in rats. J Ethnopharmacol 1996;55:27-33. View abstract.

Wiese J, McPherson S, Odden MC, Shlipak MG. Effect of Opuntia ficus indica on symptoms of the alcohol hangover. Arch Intern Med 2004;164:1334-40. View abstract.

Wolfram R, Budinsky A, Efthimiou Y, et al. Daily prickly pear consumption improves platelet function. Prostaglandins Leukot Essent Fatty Acids 2003;69:61-6. View abstract.

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