RISKS & SIDE EFFECTS

Things to know about TRELEGY:

TRELEGY is not used to relieve sudden breathing problems and will not replace a rescue inhaler.

TRELEGY should not be used in children younger than 18 years of age. It is not known if TRELEGY is safe and effective in children younger than 18 years of age.

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COPD:

• TRELEGY 100/62.5/25 mcg is a prescription medicine used long term (chronic) to treat people with chronic obstructive pulmonary disease (COPD). COPD is a chronic lung disease that includes chronic bronchitis, emphysema, or both. TRELEGY is used to improve symptoms of COPD for better breathing and to reduce the number of flare-ups (the worsening of your COPD symptoms for several days).

Asthma:

• TRELEGY is a prescription medicine used long term to prevent and control symptoms of asthma for better breathing and to prevent symptoms such as wheezing.

Do not use TRELEGY:

• to treat sudden, severe symptoms of COPD or asthma.
• if you have a severe allergy to milk proteins. Ask your healthcare provider if you are not sure.
• if you are allergic to fluticasone furoate, umeclidinium, vilanterol, or any of the ingredients in TRELEGY. See “What are the ingredients in TRELEGY?” below for a complete list of ingredients.

What should I know before starting TRELEGY?

Before using TRELEGY, tell your healthcare provider about all of your medical conditions, including if you have:

• heart problems; high blood pressure; seizures; thyroid problems; diabetes; liver problems; weak bones (osteoporosis); an immune system problem; eye problems such as glaucoma, increased pressure in your eye, cataracts, blurred vision, or other changes in vision. TRELEGY may make your glaucoma worse.

or if you:

• are allergic to milk proteins.
• have prostate or bladder problems, or problems passing urine. TRELEGY may make these problems worse.
• have any type of viral, bacterial, parasitic, or fungal infection.
• are exposed to chickenpox or measles.
• are pregnant or plan to become pregnant. It is not known if TRELEGY may harm your unborn baby.
• are breastfeeding or plan to breastfeed. It is not known if the medicines in TRELEGY pass into your breast milk and if they can harm your baby.

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Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. TRELEGY and certain other medicines may interact with each other. This may cause serious side effects. Especially tell your healthcare provider if you take: anticholinergics (including tiotropium, ipratropium, aclidinium); atropine; other long-acting beta2-adrenergic agonists (LABA) (including salmeterol, formoterol, arformoterol, olodaterol, and indacaterol); antifungal or anti-HIV medicines.

Know the medicines you take. Keep a list of them to show your healthcare provider and pharmacist when you get a new medicine.

How should I use TRELEGY?

Read the step-by-step instructions for using TRELEGY at the end of the Patient Information.

• Do not use TRELEGY unless your healthcare provider has taught you how to use the inhaler and you understand how to use it correctly.
• TRELEGY comes in 2 different strengths. Your healthcare provider prescribed the strength that is best for you.
• Use TRELEGY exactly as your healthcare provider tells you to use it. Do not use TRELEGY more often than prescribed.
• Use 1 inhalation of TRELEGY 1 time each day. Use TRELEGY at the same time each day.
• If you miss a dose of TRELEGY, take it as soon as you remember. Do not take more than 1 inhalation per day. Take your next dose at your usual time. Do not take 2 doses at 1 time.
• If you take too much TRELEGY, call your healthcare provider or go to the nearest hospital emergency room right away if you have any unusual symptoms, such as worsening shortness of breath, chest pain, increased heart rate, or shakiness.
• Do not use other medicines that contain a LABA or an anticholinergic for any reason. Ask your healthcare provider or pharmacist if any of your other medicines are LABA or anticholinergic medicines.
• Do not stop using TRELEGY unless told to do so by your healthcare provider because your symptoms might get worse. Your healthcare provider will change your medicines as needed.
• TRELEGY does not relieve sudden symptoms of COPD or asthma and you should not take extra doses of TRELEGY to relieve these sudden symptoms. Always have a rescue inhaler with you to treat sudden symptoms. If you do not have a rescue inhaler, call your healthcare provider to have one prescribed for you.
• Call your healthcare provider or get medical care right away if:
  • your breathing problems get worse.
  • you need to use your rescue inhaler more often than usual.
  • your rescue inhaler does not work as well to relieve your symptoms.

What are the possible side effects of TRELEGY?

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