What to Expect With Motegrity® (prucalopride)

Important Safety Information

Do not take Motegrity if you:

• are allergic to Motegrity. Allergic reaction symptoms may include trouble breathing, rash, itching and swelling of your face, lips, tongue or throat.
• have a tear in your stomach or intestinal wall (bowel perforation), a bowel blockage (intestinal obstruction) or serious conditions of the intestinal wall such as Crohn’s disease, ulcerative colitis.

Before taking Motegrity, tell your healthcare provider (HCP) about all of your medical conditions, including if you:

• have or have had depression, suicidal thoughts or actions, or mood problems
• have kidney problems. Your HCP may give you a lower dose of Motegrity
• are pregnant or plan to become pregnant. It is not known if Motegrity will harm your unborn baby
• are breastfeeding or plan to breastfeed. Prucalopride can pass into your breastmilk. Talk with your HCP about the best way to feed your baby if you take Motegrity.

Tell your HCP about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.

What are the possible side effects of Motegrity? Motegrity may cause serious side effects, including:

• unusual changes in mood or behavior, thoughts of hurting yourself, trying to hurt yourself, or suicide. Stop taking Motegrity right away and tell your HCP immediately if your depression gets worse, you feel sad, hopeless or begin to have thoughts of suicide, thoughts of hurting yourself or you have tried to hurt yourself or if you develop new depression.

The most common side effects of Motegrity include:

• headache
• stomach area (abdominal) pain or bloating

• nausea
• diarrhea

• dizziness
• vomiting

• gas
• fatigue

These are not all the possible side effects of Motegrity. Call your doctor for medical advice about side effects.

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You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

What is Motegrity?

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Motegrity is a prescription medicine used in adults to treat a type of constipation called chronic idiopathic constipation (CIC). Idiopathic means the cause of the constipation is unknown. It is not known if Motegrity is safe and effective in children.

Please click here for full Prescribing Information and Patient Information.

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